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Circadian Disruption may Contribute to MS Development in Youth

10/18/2011

Youth who engage in off-hour employment before the age of 20 may be at risk for MS due to a disruption in their circadian rhythm and sleep pattern, according to researchers from Sweden. Findings of this novel study appear in Annals of Neurology, a journal published on behalf of the American Neurological Association and Child Neurology Society.

Dr. Anna Karin Hedström and colleagues from the Karolinska Institutet in Stockholm analyzed data from two population-based studies—one with 1343 incident cases of MS and 2900 controls and another with 5129 prevalent MS cases and 4509 controls. The team compared the occurrence of MS among study subjects exposed to shift work at various ages against those who had never been exposed. All study subjects resided in Sweden and were between the ages of 16 and 70. Shift work was defined as permanent or alternating working hours between 9 p.m. and 7 a.m.

Results showed that those in the incident MS cohort who had worked off-hour shifts for three years or longer before age 20 had a 2 fold-risk of developing MS compared with those who never worked shifts. Similarly, subjects in the prevalent cohort who engaged in shift work as teens had slightly more than a 2-fold risk of MS than subjects who never worked shifts.

"Our analysis revealed a significant association between working shift at a young age and occurrence of MS," explains Dr. Hedström. "Given the association was observed in two independent studies strongly supports a true relationship between shift work and disease risk."

The authors suggest that while disruption of circadian rhythm and sleep loss may play a role in the development of MS, the exact mechanisms behind this increased risk remain unclear and further study is needed.

Previous research has determined that shift work—working during the night or rotating working hours—increases the risk of cardiovascular disease, thyroid disorders, and cancer. Circadian disruption and sleep restriction are associated with working night shifts; these factors are believed to disturb melatonin secretion and increase inflammatory responses, promoting disease states. MS is a central nervous system autoimmune inflammatory disorder that is thought to have an important environmental component, thus investigating lifestyle risk factors, such as sleep loss related to shift work, was an important objective and the focus of the current study.

 



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